We describe a recent approach for distinguishing between stochastic and deterministic sources of variability, focusing on the mammalian cell cycle. Variability between cells is often attributed to stochastic noise, although it may be generated by deterministic components. Interestingly, lineage information can be used to distinguish between variability and determinism. Analysis of correlations within a lineage of the mammalian cell cycle duration revealed its deterministic nature. Here, we discuss the sources of such variability and the possibility that the underlying deterministic process (...) is due to the circadian clock. Finally, we discuss the “kicked cell cycle” model and its implication on the study of the cell cycle in healthy and cancerous tissues. (shrink)

INTRODUCTIONA PRELIMINARY NOTEI. THE PRESENT SCOPE AND SUBSTANCE OF SPERM DONORS’LEGAL AND ETHICAL OBLIGATIONSII. DUTY-BOUND SPERM DONORSA. Delineating the Suggested Ethical ObligationB. Is It the Genetic Link that Morally Binds Sperm Donors by Donor-Duty?III. SUPPORTIVE EVIDENCE FOR RECEPTIVENESS TO DONORDUTY: THE CASE OF DE-ANONYMIZATION OF SPERM DONORSA. Relevant Implications of the Removal of Donor AnonymityIV. ANALOGIZING DONOR-DUTY TO THE DUTY NOT TO INFECT OTHERSA. Mode of TransmissionB. The Public Health PerspectiveC. The Duty to WarnV. COMPETING RIGHTSA. The DCC’s Right to (...) Know Health-Related Information vs. the Donor’s Right to PrivacyB. The DCC’s Right to Know Health-Related Information vs. the Donor’s .. (shrink)

We argue that a comprehensive theory of reciprocals must rely on a general taxonomy of restrictions on the interpretation of relational expressions. Developing such a taxonomy, we propose a new principle for interpreting reciprocals that relies on the interpretation of the relation in their scope. This principle, the Maximal Interpretation Hypothesis (MIH), analyzes reciprocals as partial polyadic quantifiers. According to the MIH, the partial quantifier denoted by a reciprocal requires the relational expression REL in its scope to denote a maximal (...) relation in REL’s interpretation domain. In this way the MIH avoids a priori assumptions on the available readings of reciprocal expressions, which are necessary in previous accounts. Relying extensively on the work of Dalrymple et al. (Ling Philos 21:159–210, 1998), we show that the MIH also exhibits some observational improvements over Dalrymple et al.’s Strongest Meaning Hypothesis (SMH). In addition to deriving some attested reciprocal interpretations that are not expected by the SMH, the MIH offers a more restrictive account of the way context affects the interpretation of reciprocals through its influence on relational domains. Further, the MIH generates a reciprocal interpretation at the predicate level, which is argued to be advantageous to Dalrymple et al.’s propositional selection of reciprocal meanings. More generally, we argue that by focusing on restrictions on relational domains, the MIH opens the way for a more systematic study of the ways in which lexical meaning, world knowledge and contextual information interact with the interpretation of quantificational expressions. (shrink)

Along with pitch and loudness, timbre is commonly described as an audible property of sounds. This paper puts forward an alternative view—that timbres are properties of auditory media. This approach has many advantages. First, it accounts for the frequent attribution of timbres to objects that do not have characteristic sounds. Second, it explains why timbres are attributed not only to ordinary objects, like musical instruments, but also to surrounding spaces and architectural structures. And finally, it provides an original solution to (...) the timbre-constancy problem. (shrink)

In this Article we propose an analytical framework for allocating responsibility for the protection of worker’s rights in the global labor market. Since production and services have expanded globally, and the state’s ability to protect worker’s rights on the national level has been undermined, the main challenge today is to find the appropriate institutional arrangements that allocate responsibility in a manner that realizes basic labor standards. The Article argues that in the context of a global labor market, responsibility should be (...) perceived in terms of "shared responsibility," whereby responsibility is shared by a complex network of agents and institutions that take part in global production and services. Within these global social networks and connections, labor relations generate a unique type of social connection which implies a special type of commitment and obligation towards workers. We propose four principles to guide the allocation of responsibility for remedying the unjust conditions of workers in the world, based on measures of connectedness, capacity, benefit, and contribution. (shrink)

Along with hallucinations and illusions, afterimages have shaped the philosophical debate about the nature of perception. Often referred to as optical or visual illusions, experiences of afterimages have been abundantly exploited by philosophers to argue against naïve realism. This paper offers an alternative account to this traditional view by providing a tentative account of the colors of the afterimages from an objectivist perspective. Contrary to the widespread approach to afterimages, this paper explores the possibility that the colors of afterimages are (...) not ontologically different from “ordinary” colors and that experiences of afterimages fail to provide a motivation for rejecting naïve realism. (shrink)

The paper outlines the history of the Babi-Baha'i Faith, its main doctrines and practices.

Are nonconscious processes sufficient to cause false memories of a nonstudied event? To investigate this issue, we controlled and measured conscious processing in the DRM task, in which studying associates causes false memories of nonstudied associates . During the study phase, subjects studied visually masked associates at extremely rapid rates, followed by immediate recall. After this initial phase, nonstudied test words were rapidly presented for perceptual identification, followed by recognition memory judgments. On the perceptual identification task, we found significant priming (...) of nonstudied associates, relative to control words. We also found significant false recognition of these nonstudied associates, even when subjects did not recall this word at study or identify it at test, indicating that nonconscious processes can cause false recognition. These recognition effects were found immediately after studying each list of associates, but not on a delayed test that occurred after the presentation of several intervening lists. Nonconscious processes are sufficient to cause this memory illusion on immediate tests, but may be insufficient for more vivid and lasting false memories. (shrink)

Freedom of association operates as an organizational "meta-norm," appreciated both as an independent value and as a touchstone for the institutional design of the International Labour Organization . Despite the renewed interest of the ILO in various aspects of the norm, its understanding of freedom of association lacks a comprehensive normative framework. This article presents such a conceptual framework and a critical in-depth analysis of current ILO freedom of association jurisprudence. Freedom of association should be understood in terms of equitable (...) dialogue , a term offered and developed herein, as an understanding that is already partly embedded in ILO jurisprudence. (shrink)

I propose a description of one aspect of the philosophical problem about the ontology of colors by formulating and motivating six plausible premises that seem to be hard to deny in isolation but that are jointly incoherent. I briefly sketch a solution and comment on the views presented in this volume from the perspective of the puzzle.

The “received wisdom” in contemporary analytic philosophy is that intuition talk is a fairly recent phenomenon, dating back to the 1960s. In this paper, we set out to test two interpretations of this “received wisdom.” The first is that intuition talk is just talk, without any methodological significance. The second is that intuition talk is methodologically significant; it shows that analytic philosophers appeal to intuition. We present empirical and contextual evidence, systematically mined from the JSTOR corpus and HathiTrust’s Digital Library, (...) which provide some empirical support for the second rather than the first hypothesis. Our data also suggest that appealing to intuition is a much older philosophical methodology than the “received wisdom” alleges. We then discuss the implications of our findings for the contemporary debate over philosophical methodology. (shrink)

Causality offers the first comprehensive coverage of causal analysis in many sciences, including recent advances using graphical methods. Pearl presents a unified account of the probabilistic, manipulative, counterfactual and structural approaches to causation, and devises simple mathematical tools for analyzing the relationships between causal connections, statistical associations, actions and observations. The book will open the way for including causal analysis in the standard curriculum of statistics, artificial intelligence, business, epidemiology, social science and economics.

Written by one of the preeminent researchers in the field, this book provides a comprehensive exposition of modern analysis of causation. It shows how causality has grown from a nebulous concept into a mathematical theory with significant applications in the fields of statistics, artificial intelligence, economics, philosophy, cognitive science, and the health and social sciences. Judea Pearl presents and unifies the probabilistic, manipulative, counterfactual, and structural approaches to causation and devises simple mathematical tools for studying the relationships between causal (...) connections and statistical associations. Cited in more than 2,100 scientific publications, it continues to liberate scientists from the traditional molds of statistical thinking. In this revised edition, Judea Pearl elucidates thorny issues, answers readers' questions, and offers a panoramic view of recent advances in this field of research. Causality will be of interest to students and professionals in a wide variety of fields. Dr Judea Pearl has received the 2011 Rumelhart Prize for his leading research in Artificial Intelligence and systems from The Cognitive Science Society. (shrink)

This article illustrates how a collaborative research process can successfully engage an underserved minority community to address health disparities. Pacific Islanders, including the Marshallese, are one of the fastest growing US populations. They face significant health disparities, including extremely high rates of type 2 diabetes. This article describes the engagement process of designing patient‐centered outcomes research with Marshallese stakeholders, highlighting the specific influences of their input on a randomized control trial to address diabetes. Over 18 months, an interdisciplinary research team (...) used community‐based participatory principles to conduct patient‐engaged outcomes research that involved 31 stakeholders in all aspects of research design, from defining the research question to making decisions about budgets and staffing. This required academic researcher flexibility, but yielded a design linking scientific methodology with community wisdom. (shrink)

The book can also be used as an excellent text for graduate-level courses in AI, operations research, or applied probability.

Judea Pearl has been at the forefront of research in the burgeoning field of causal modeling, and Causality is the culmination of his work over the last dozen or so years. For philosophers of science with a serious interest in causal modeling, Causality is simply mandatory reading. Chapter 2, in particular, addresses many of the issues familiar from works such as Causation, Prediction and Search by Peter Spirtes, Clark Glymour, and Richard Scheines. But philosophers with a more general interest (...) in causation will also profit from reading Pearl’s book, especially the material in chapters 7, 9, and 10, which is self-contained and less technical than other parts of the book. The present review is aimed primarily at readers of the second type. (shrink)

We support Jaswal & Akhtar's interrogation of social motivational accounts of autism and discuss two sources of bias that contribute to how others construe autistic people's communications: an experience-based bias that limits our ability to discern the speaker's action as communicative and a prejudice against the credibility of certain speakers that limits a listener's willingness to believe their testimony.

The following Addenda and some Corrigenda were derived for the most part from manuscripts examined in the summer of 1964 and in the spring and summer of 1965, 1967 at Bologna University ; London, British Museum ; Munich, Bayerische Staats-Bibliothek, Codex Latinus Monacensis ; Orlèans; Oxford, the Bodleian ; and Merton College ; Paris, Bibliotheque nationale , and University ; Tours; Vatican, Bibliotheca Apostolica Vaticana ; and Vienna, National-Bibliothek . A number are noted from other sources, namely Silvestre , Wickersheimer (...) , et alia. They supplement the late Lynn Thorndike's “Additional Addenda et Corrigenda” in Speculum , and are here offered for the convenience of users of the Catalogue of Incipits. jQuery.click { event.preventDefault(); }). (shrink)

In the vast literature centering on the Itinerarium Egeriae there is a serious lacuna. No attempt has been made to analyse the circle of readers to whom this remarkable document was addressed and for whose sake Egeria recorded so faithfully every detail of her journey. Yet if a full understanding of the IE is to be achieved, some definition of the circle of Egeria and of its relations with the pilgrim is essential. In other words, who in the West at (...) that point in the late fourth century, would have been so interested in Holy Land pilgrimage as to read attentively such a personal account as the IE? The following is a tentative essay to gauge the concerns, expectations and cultural background of Egeria's immediate circle of readers through her own emphasis on various aspects of her pilgrimage. In addition, the investigation will try to assess the place of pilgrimage in the life of western communities and the value of communications between the pilgrim on the road and the society back at home. (shrink)

Everyone has heard the claim, "Correlation does not imply causation." What might sound like a reasonable dictum metastasized in the twentieth century into one of science's biggest obstacles, as a legion of researchers became unwilling to make the claim that one thing could cause another. Even two decades ago, asking a statistician a question like "Was it the aspirin that stopped my headache?" would have been like asking if he believed in voodoo, or at best a topic for conversation at (...) a cocktail party rather than a legitimate target of scientific inquiry. Scientists were allowed to posit only that the probability that one thing was associated with another. This all changed with Judea Pearl, whose work on causality was not just a victory for common sense, but a revolution in the study of the world. (shrink)

In this paper, I propose that the debate in epistemology concerning the nature and value of understanding can shed light on the role of scientific idealizations in producing scientific understanding. In philosophy of science, the received view seems to be that understanding is a species of knowledge. On this view, understanding is factive just as knowledge is, i.e., if S knows that p, then p is true. Epistemologists, however, distinguish between different kinds of understanding. Among epistemologists, there are those who (...) think that a certain kind of understanding—objectual understanding—is not factive, and those who think that objectual understanding is quasi-factive. Those who think that understanding is not factive argue that scientific idealizations constitute cognitive success, which we then consider as instances of understanding, and yet they are not true. This paper is an attempt to draw lessons from this debate as they pertain to the role of idealizations in producing scientific understanding. I argue that scientific understanding is quasi-factive. (shrink)

Effective stress management strategies correlate with improved academic performance in college students, yet inconsistent findings in existing research warrant further investigation. This study explored the intricate interplay between stress levels, coping strategies, and academic achievement in HyFlex learningenvironments. A stratified random sample of 111 students from five specializations within the Bachelor of Secondary Education program participated. Utilizing a descriptive-correlational design, data were collected through validated self-report questionnaires and a weighted general average. Subsequent descriptive statistics and bivariate correlation analysis revealed moderate (...) stress levels among participants who preferred task-oriented coping strategies. Interestingly, a significant positive association was observed between stress levels and academic achievement and emotion-oriented coping strategies, while a negative correlation emerged between stress and task-oriented coping strategies. Avoidance-oriented coping strategies, conversely, displayed a significant negative association with academic success. These findings underscore the crucial role of educational institutions in providing robust support mechanisms for stress management and cultivating a task-focused learning environment to optimize student well-being and academic performance within the HyFlex model. (shrink)

We extend Tomasello's discussion of children's developing sense of obligation to testimonial learning. First, we review a battery of behaviors in testimonial exchanges that parallel those described by Tomasello. Second, we explore the variable ways in which children hold others accountable, suggestive that children's evaluations of moral and epistemic responsibilities in joint collaborative activities are distinct.

In this paper, I consider the pessimistic induction construed as a deductive argument (specifically, reductio ad absurdum) and as an inductive argument (specifically, inductive generalization). I argue that both formulations of the pessimistic induction are fallacious. I also consider another possible interpretation of the pessimistic induction, namely, as pointing to counterexamples to the scientific realist’s thesis that success is a reliable mark of (approximate) truth. I argue that this interpretation of the pessimistic induction fails, too. If this is correct, then (...) the pessimistic induction is an utter failure that should be abandoned by scientific anti-realists. (shrink)

We propose a new definition of actual causes, using structural equations to model counterfactuals. We show that the definition yields a plausible and elegant account of causation that handles well examples which have caused problems for other definitions and resolves major difficulties in the traditional account.

There is an ongoing methodological debate in philosophy of science concerning the use of case studies as evidence for and/or against theories about science. In this paper, I aim to make a contribution to this debate by taking an empirical approach. I present the results of a systematic survey of the PhilSci-Archive, which suggest that a sizeable proportion of papers in philosophy of science contain appeals to case studies, as indicated by the occurrence of the indicator words “case study” and/or (...) “case studies.” These results are confirmed by data mined from the JSTOR database on research articles published in leading journals in the field: Philosophy of Science, the British Journal for the Philosophy of Science (BJPS), and the Journal for General Philosophy of Science (JGPS), as well as the Proceedings of the Biennial Meeting of the Philosophy of Science Association (PSA). The data also show upward trends in appeals to case studies in articles published in Philosophy of Science, the BJPS, and the JGPS. The empirical work I have done for this paper provides philosophers of science who are wary of the use of case studies as evidence for and/or against theories about science with a way to do philosophy of science that is informed by data rather than case studies. (shrink)

We show in this paper that the AGM postulates are too weak to ensure the rational preservation of conditional beliefs during belief revision, thus permitting improper responses to sequences of observations. We remedy this weakness by proposing four additional postulates, which are sound relative to a qualitative version of probabilistic conditioning. Contrary to the AGM framework, the proposed postulates characterize belief revision as a process which may depend on elements of an epistemic state that are not necessarily captured by a (...) belief set. We also show that a simple modification to the AGM framework can allow belief revision to be a function of epistemic states. We establish a model-based representation theorem which characterizes the proposed postulates and constrains, in turn, the way in which entrenchment orderings may be transformed under iterated belief revision. (shrink)

It is a common view among philosophers of science that theoretical virtues (also known as epistemic or cognitive values), such as simplicity and consistency, play an important role in scientific practice. In this article, I set out to study the role that theoretical virtues play in scientific practice empirically. I apply the methods of data science, such as text mining and corpus analysis, to study large corpora of scientific texts in order to uncover patterns of usage. These patterns of usage, (...) in turn, might shed some light on the role that theoretical virtues play in scientific practice. Overall, the results of this empirical study suggest that scientists invoke theoretical virtues explicitly, albeit rather infrequently, when they talk about models (less than 30%), theories (less than 20%), and hypotheses (less than 15%) in their published works. To the extent that they are mentioned in scientific publications, the results of this study suggest that accuracy, consistency, and simplicity are the theoretical virtues that scientists invoke more frequently than the other theoretical virtues tested in this study. Interestingly, however, depending on whether they talk about hypotheses, theories, or models, scientists may invoke one of those theoretical virtues more than the others. (shrink)

In this paper, I present the results of an experimental study on intuitions about moral obligation (ought) and ability (can). Many philosophers accept as an axiom the principle known as “Ought Implies Can” (OIC). If the truth of OIC is intuitive, such that it is accepted by many philosophers as an axiom, then we would expect people to judge that agents who are unable to perform an action are not morally obligated to perform that action. The results of my experimental (...) study show that participants were more inclined to judge that an agent ought to perform an action than that the agent can perform the action. Overall, participants said that an agent ought to perform an action even when they said that the agent cannot do it. I discuss the implications of these results for the debate over OIC. (shrink)

Experimental philosophers have challenged friends of the expertise defense to show that the intuitive judgments of professional philosophers are different from the intuitive judgments of nonphilosophers, and the intuitive judgments of professional philosophers are better than the intuitive judgments of nonphilosophers, in ways that are relevant to the truth or falsity of such judgments. Friends of the expertise defense have responded by arguing that the burden of proof lies with experimental philosophers. This article sketches three arguments which show that both (...) and are probably false. If its arguments are cogent, then shifting the burden of proof is a futile move, since philosophical training makes no difference so far as making intuitive judgments in response to hypothetical cases is concerned. (shrink)

In this paper, I argue that the ultimate argument for Scientific Realism, also known as the No-Miracles Argument (NMA), ultimately fails as an abductive defence of Epistemic Scientific Realism (ESR), where (ESR) is the thesis that successful theories of mature sciences are approximately true. The NMA is supposed to be an Inference to the Best Explanation (IBE) that purports to explain the success of science. However, the explanation offered as the best explanation for success, namely (ESR), fails to yield independently (...) testable predictions that alternative explanations for success do not yield. If this is correct, then there seems to be no good reason to prefer (ESR) over alternative explanations for success. (shrink)